Studies have never defined a “normal” level of sexual desire. Despite that, there’s a website and an online quiz to help you decide if you’ve got a problem. Called “Right to Desire,” it brands libido as a feminist “right,” and its home page offers the defiant, in-your-face prompt: “Yes, I want my desire back.”
Click a few boxes and you’re instantly directed to a remedy (and an online doctor to prescribe it): a pill called Addyi from Sprout Pharmaceuticals.비아그라 구입 “This particular product should not have been approved by FDA, but it was, and it is not a product that adds value to women’s lives,” said Susan Wood, assistant commissioner for women’s health at the Food and Drug Administration from 2000 to 2005. She added: “There isn’t an actual market.” ADVERTISEMENTThe effort, called a “disease awareness” campaign, troubles critics because it attempts to define low sexual desire as a widespread disease that is treatable with a pill. Although doctors recognize that there is (perhaps) a condition called Hypoactive Sexual Desire Disorder, many of the studies defining HSDD were sponsored by the drugmaker. Almost all doctors on the 2016 consensus panel that defined HSDD were consultants or on Sprout’s advisory board. To further complicate matters, in the studies that led to Addyi’s approval, results were not terribly impressive. And, for those who would simply like a little more sex in their lives, is it worth a $400-a-month pill? INQUIRER MORNING NEWSLETTERGet the news you need to start your day Sign Up Enter the latest sales pitch, which encourages women to stand up for their rights. The new campaign taps into emotional issues that have long been staples of women’s equality movements, like the right to equal access to health care and the idea that women’s issues should be taken as seriously as men’s. “To hear our language co-opted” is upsetting, Cindy Pearson, the executive director of the National Women’s Health Network, said. “It’s really bittersweet to see it co-opted to sell, and sell a product that isn’t that good.” ADVERTISEMENTAddyi — also known as flibanserin — first gained FDA approval in 2015 after a long and contentious fight. It’s often called the “female Viagra” because it’s related to sex, but Addyi and erectile dysfunction meds are quite different.시알리스 구입 While impotence medications work by directing blood to the genitals and are taken before sex, Addyi is taken nightly and works in the brain to increase desire. In fact, it was originally developed to be an antidepressant, but its clinical-trial performance fell short. Along the way, researchers noticed that subjects reported having some increase in sexual desire. On average, women who took it reported one increased sexually gratifying experience every other month, and that was only after the subjects began recording their experiences monthly instead of daily. There are also concerns about side effects like dangerously low blood pressure, fainting, severe drowsiness, and insomnia. The FDA rejected Addyi twice before it went before a public advisory council, where patients, doctors, and women’s groups (some funded by the manufacturer, say industry researchers) testified for the drug. It’s difficult to pinpoint the number of women who report a persistent lack of sexual desire. Even the findings of studies sponsored by the drugmaker vary widely. Such complaints also tend to be more common among post-menopausal women — a group for whom the drug is not approved. Experts say it’s difficult to get an accurate picture of the problem medically known as low libido because it has so many possible causes — depression, poor body image, fatigue, stress, pregnancy, and menopause. Even in the Sprout-sponsored study, many women who were distressed about their low sexual desire ascribed it to “relationship issues.” ADVERTISEMENTAddyi’s labeling expressly notes it is not approved for use by women whose low libido is caused by problems in their relationships, menopause, childbirth, medical issues, other medications they are taking, or mental illness. Before Addyi was approved, a coalition of groups — some venerated women’s rights groups and some that were formed and funded by the pharmaceutical industry — known as “Even the Score” pushed for the drug’s approval and found traction. The rallying cry was the idea that 26 drugs had been approved for male sexual dysfunction and none for women. “I believe [the FDA] found it hard to keep the product off the market when they were being accused of being sexist,” Wood said. “They got, in my view, sort of bamboozled by that argument.” Forty-eight hours after Addyi was approved, Sprout sold it to Valeant, now under the umbrella of Bausch Health Companies, for around $1 billion.시알리스 구매 And it flopped. According to Wood, that’s because the drug didn’t work, came with safety concerns, and wasn’t covered by many insurance plans. At its peak in March 2016, only 1,600 prescriptions were written for it. In 2017, Valeant gave up on Addyi, turning it back over to Sprout, which is now trying again to make the drug a sensation. As part of the arrangement, according to press reports, Sprout did not have to pay an upfront fee and, among other parts of the deal, agreed to pay Valeant, now Bausch, royalties on sales of the drug, though early indications say it still isn’t successful. “We will receive royalties once they make a milestone,” Arthur Shannon, senior vice president and head of investor relations and communications for Bausch, wrote in an email. “We have not received any royalties thus far.” In any case, Addyi may soon have competition. Palatin Technologies is seeking approval of bremelanotide, trade-named Vyleesi, a synthetic hormone that helps activate brain receptors involved in sexual responses. The FDA is scheduled to complete its review of Palatin’s application next month. Staff writer Marie McCullough contributed to this report. https://viagra-onlineshop.com/ Posted: May 10, 2019 - 9:28 AM Rachel Bluth, Kaiser Health News 출처 : https://www.inquirer.com/health/sexual-desire-addyi-female-viagra-20190510.html
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[비아그라 구매방법]Phony Viagra pills, male enhancement drugs seized by Customs agents at Rochester airport9/12/2019 Rochester, N.Y. – Thousands of prescription pills totaling nearly $60,000 were seized during an investigation by U.S. Customs and Border Protection at the Greater Rochester International Airport.비아그라 구입
During an inspection of express consignment shipments, agents say they found bottles of Viagra and Cialis that were later determined to be counterfeit. In total, they found 210 fake Viagra pills – with an MSRP value of nearly $15,000 – and more than 1,700 fake Cialis pills, valued at more than #26,000. CBP Buffalo✔@CBPBuffalo#CBP Officers at the #RochesterAirport discovered > $60,000 in combined counterfeit and unlawful Prescription Pills (Viagra, Cialis, Black Gorilla, Australia) #AlwaysVigilant #RochesterNY http://bit.ly/2TNslcL 시알리스 구입 2 6:11 AM - Apr 2, 2019 Twitter Ads info and privacy See CBP Buffalo's other Tweets Agents also reportedly discovered 600 pills each of male enhancement medications Black Gorilla and Australia, valued at nearly $20,000. The items were seized under the Federal Food, Drug and Cosmetic Act, which prohibits incorrectly branded or degraded goods from being introduced into interstate commerce. In a statement, Rochester Port Director Ronald Menz said, “Our CBP Officers in Rochester continue to utilize their skills and expertise to target and identify prohibited merchandise. Our officers work day in and day out to protect our community ensuring that illicit items are not entering our country.” https://viagra-onlineshop.com/ 출처 : https://13wham.com/news/local/phony-viagra-pills-male-enhancement-drugs-seized-by-customs-agents-at-rochester-airport Viagra’s famously surprising origin story is actually a pretty common way to find new drugs9/12/2019 All seemed to be going well—except for one weird thing the men enrolled in the study did when nurses went to check on them. “They found a lot of the men were lying on their stomachs,” John LaMattina, who was the head of research and development at Pfizer while this research was ongoing, said on a 2016 episode of the STAT Signal Podcast (listen in around 7:15). ”A very observant nurse reported this, saying the men were embarrassed [because] they were getting erections.” It appeared that the blood vessels dilating were not in the heart, but rather the penis (dilating blood vessels is part of the process that leads to erections).
All seemed to be going well—except for one weird thing the men enrolled in the study did when nurses went to check on them. “They found a lot of the men were lying on their stomachs,” John LaMattina, who was the head of research and development at Pfizer while this research was ongoing, said on a 2016 episode of the STAT Signal Podcast (listen in around 7:15). ”A very observant nurse reported this, saying the men were embarrassed [because] they were getting erections.” It appeared that the blood vessels dilating were not in the heart, but rather the penis (dilating blood vessels is part of the process that leads to erections).비아그라 구입 The sildenafil was working—but in the wrong part of the body. And with that, the so-called “potency pill” was born. Viagra was approved by the US Food and Drug Administration for use as an erectile dysfunction drug in 1998. About a decade later, researchers began running new clinical trials to see if it could double as a heart drug as originally intended. Sure enough, in 2005, the FDA approved the same compound for a heart condition called pulmonary arterial hypertension, which constricts the blood flow to the lungs and affects both men and women. The drug that makes Viagra work is now also sold under the name Revatio, for pulmonary arterial hypertension. 시알리스 구매 This isn’t that abnormal. Scientists know how individual parts of the body work, but how all the body’s systems work together is still somewhat of a mystery. Occasionally, this means scientists will know that a drug works, but won’t understand exactly how—and that means new uses for old drugs are found all the time. Recently, a large-scale clinical trial found that canakinumab (Ilaris) a drug used to treat one form of arthritis made by Novartis, could also be used to treat heart disease after researchers understood that inflammation may play a role in the latter. Before that, in 2008, the compound bimatoprost (Lumigen), which was made by Allergan to treat high eye pressure, was approved to enhance eyelash growth under the name Latisse after people taking it kept reporting the glamorous side effect. And the compound finasteride was first used in the drug Proscar, made by Merck, to treat swollen prostates, but was later approved to treat baldness under the name Propecia when patients reported they noticed hair changes after taking the drug. (Some people taking finasteride have reported some fairly horrific side effects, in some cases long-term.) In all of these cases, the second application was found after the drug was on the market for a while. As larger populations take a given drug for longer periods of time, there’s a chance for new side effects that didn’t show up even in the largest stage three clinical trials to be uncovered. This is why it’s important to report all side effects—and not just the bad ones—to your doctor, regulatory agencies, or even the drug companies themselves. It could improve or even save lives. In addition, it’s clear that it’s worth researchers’ time to keep investigating a drug that already “works” in case it turns out to have applications for other conditions that scientists didn’t recognize before. The more data, the better. 시알리스 구입 While drug discovery does involve a lot of research and development, it also involves serendipity and spotting unusual details. If that one nurse hadn’t reported her participants’ reactions to sildenafil, the world wouldn’t have had Viagra. This same kind of luck and vigilance could uncover new uses for existing treatments. Sign up for the Quartz Daily Brief email Sign me up https://viagra-onlineshop.com/ Stay updated about Quartz products and events. technology, science, health, pharma, pfizer Recent headlines about a case report published in the fall issue of Retinal Cases & Brief Reports gave the false impression that a man developed red-tinted vision after using Viagra. In the retrospective article, a team of physicians describe the precarious situation of a 31-year-old man who took a big dose of sildenafil citrate, the active ingredient in Viagra, in order to treat his erectile dysfunction. Instead of the intended effect, the man developed red-tinted vision. It’s alarming stuff, but a close look at the paper reveals one crucial detail: The man did not take Viagra itself.비아그라 구입
The confusion seems to stem from an accompanying press release, published by New York’s Mount Sinai Hospital on Monday, which strongly suggested that Viagra was to blame. In the original release, which has since been edited, hospital representatives stated: “researchers have shown that color vision problems caused by retinal damage on a cellular level can result from a high dose of sildenafil citrate, the popular erectile dysfunction medication sold under the brand name Viagra.” The paper is not available online, but Inverse obtained it from Mount Sinai Hospital in PDF form. The paper is not available online, but Inverse obtained it from Mount Sinai Hospital in PDF form. Running with this statement, subsequent media reports ran headlines claiming that Viagra can cause damage to eyes.시알리스 구입 A screenshot of the original press release posted to Mount Sinai's website.But a close look at the paper shows no evidence that that the patient actually took Viagra. He endangered himself with something far riskier: a counterfeit version of the drug sold on the internet. Liquid Sildenafil Citrate ≠ ViagraWhat the patient actually took was a liquid version of Viagra’s active chemical, sildenafil citrate. Furthermore, the researchers didn’t conduct further studies on patients who use other Pfizer products. https://viagra-onlineshop.com/ “Pfizer is aware of media reports incorrectly citing Viagra as the medicine linked to a case report issued by Mount Sinai Hospital,” Pfizer director of media relations Steve Danehy tells Inverse. “According to the hospital statement, the individual actually purchased liquid sildenafil online, with no indication whether a prescription was provided, and then ingested an unspecified dosage. It’s important to note that no regulatory body has approved liquid sildenafil citrate to treat erectile dysfunction.” At the time of publishing, Mount Sinai has not responded to Inverse’s request for comment. The research team includes physicians from Mount Sinai, Columbia University, and the New York University School of Medicine. 출처 : https://www.inverse.com/article/49514-sildenafil-citrate-color-vision-damage |
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